The Energy Committee said it was "sceptical" that Britain's target of switching on two nuclear power stations a year between 2020 and 2025 would be reached.
The UK needs a huge number of new nuclear power stations to make up for the coal-fired stations being switched off over the next decade.
However, the committee warned that the Coalition's new planning system did not appear to be capable of making sure the 12 new stations are located in the right places to be linked up to the electricity grid.
"Hooking up this amount of nuclear and other generation to the national grid poses an unprecedented challenge," said Tim Yeo, its chairman. "Two plants a year is a very high target to reach. The [system] lacks any real framework for coordinating the process of siting and linking up the new power stations."